Calibrator: UniCal ACE

Angiotensin converting enzyme (ACE, dipeptidyl carboxypeptidase) is a glycoprotein peptidyl dipeptide hydrolase that cleaves histidyl leucine dipeptide from angiotensin I, a relatively inactive decapeptide. The latter is converted to the potent vasoconstrictor, angiotensin II. ACE also inactivates bradykinin. Elevated levels of ACE activity occur in serum of patients with active sarcoidosis, and occasionally in premature infants with respiratory distress syndrome, in adults with tuberculosis, Gaucher’s disease, leprosy, and in many other pathologic conditions involving lung and liver diseases.